Scientific Library
There is a growing mountain of evidence to support the role cannabis can play in a wide range of health problems and diseases. Below are links to some cannabis studies on some common health conditions.
- Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders
- Subtypes of ADHD and cannabis use
- Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students
- ADHD Is Highly Prevalent in Patients Seeking Treatment for Cannabis Use Disorders
- A Qualitative Analysis of Online Forum Discussions on Cannabis Use and ADHD
- Cannabinoids in attention-deficit/hyperactivity disorder: a randomized controlled trial
- CBD as an Intervention for Addictive Behaviors
- CBD reduces cigarette consumption in tobacco smokers
- CBD inhibits the reward-facilitating effect of morphine
- Cannabidiol, a non-psychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances
- CBD for the treatment of cannabis withdrawal syndrome
- CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
- Early Phase in the Development of CBD as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage
- Cannabinoids for the Treatment of Agitation and Aggression in Alzheimer’s Disease.
- The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
- Endocannabinoid signalling in Alzheimer’s disease
- Neurological aspects of the medical use of CBD
- In vivo Evidence for Therapeutic Properties of CBD for Alzheimer’s Disease
- CBD Modulates the Expression of Alzheimer’s Disease-Related Genes in Mesenchymal Stem Cells
- The Potential Therapeutic Effects of THC on Alzheimer’s Disease
- The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease
- The role of the endocannabinoid system in Alzheimer’s disease
- Can Marijuana Prevent Alzheimer’s?
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa unselected population of patients with cancer.
- CBD reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
- Neural basis of anxiolytic effects of CBD in generalized social anxiety disorder
- A systematic review of plant-derived natural compounds for anxiety disorders
- CBD regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
- Involvement of the endocannabinoid system in osteoarthritis pain
- The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
- Preliminary assessment of the efficacy, tolerability, and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
- Endocannabinoid Signaling in Autism
- A novel approach to the symptomatic treatment of autism
- Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
- Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
- The effect of cannabidiol (CBD) on low-frequency activity and functional connectivity in the brain of adults with and without autism spectrum disorder (ASD)
- Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer.
- CBD as potential anticancer drug
- The inhibitory effects of CBD on systemic malignant tumors
- CBD inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
- Antitumorigenic targets of cannabinoids – current status and implications
- The Influence of Biomechanical Properties and Cannabinoids on Tumor Invasion
- Cannabinoids – a new weapon against cancer?
- Towards the use of non-psychoactive cannabinoids for prostate cancer.
- Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism.
- Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.
- CBD inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
- CBD-Induced Apoptosis in Human Leukemia Cells
- Endocannabinoids in endocrine and related tumours
- Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
- Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase-dependent.
- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
- CBD induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
- Pathways mediating the effects of CBD on the reduction of breast cancer cell proliferation, invasion, and metastasis
- CBD as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
- CBD-A mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells
- Antitumor effects of CBD, a nonpsychoactive cannabinoid, on human glioma cell lines
- A systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
- Cannabis improved survival of patients with aggressive brain cancer in controlled clinical study
- The Role of Cannabinoids as Anticancer Agents in Pediatric Oncology
- Oral THC:CBD cannabis extract for refractory chemotherapy-induced nausea and vomiting: a randomised, placebo-controlled, phase II crossover trial
- Cannabis finds its way into treatment of Crohn’s disease.
- Treatment of Crohn’s disease with cannabis: an observational study.
- CBD in inflammatory bowel diseases: a brief overview
- Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
- Cannabinoids and the gut: New developments and emerging concepts
- Endocannabinoids and the gastrointestinal tract
- Manipulation of the Endocannabinoid System in Colitis: A Comprehensive Review
- patients with cancer.
- Antidepressant-Like and Anxiolytic-Like Effects of CBD
- Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: the role of 5-HT1A receptors
- The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants
- Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
- Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa
- The putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
- Endocannabinoid signaling in the etiology and treatment of major depressive illness
- The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
- CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death
- CBD lowers incidence of diabetes in non-obese diabetic mice
- Neuroprotective and blood-retinal barrier-preserving effects of CBD in experimental diabetes
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
- The endocannabinoid system in obesity and type 2 diabetes
- Cannabinoids and endocannabinoids in metabolic disorders with a focus on diabetes
- The endocannabinoid system and plant-derived cannabinoids in diabetes and diabetic complications
- Efficacy and Safety of CBD and THC-V on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes
- Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
- From Cannabis to Cannabidiol to Treat Epilepsy, Where Are We?
- Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome.
- Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy.
- Cannabinoids for epilepsy.
- Cannabis, cannabidiol, and epilepsy–from receptors to clinical response.
- Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
- Endocannabinoid system protects against cryptogenic seizures.
- Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
- The cannabinoids as potential antiepileptics
- Pharmacology of cannabinoids in the treatment of epilepsy
- Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy
- The therapeutic effects of Cannabis and cannabinoids: An update from the National Academies of Sciences, Engineering and Medicine report.
- Cannabinoids: Medical implications.
- Safety and side effects of cannabidiol
- CBD as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.
- CBD: From an inactive cannabinoid to a drug with wide spectrum of action
- CBD: An overview of some pharmacological aspects.
- Clinical Studies With Cannabis and Cannabinoids, 2005-2009
- CBD: An overview of some chemical and pharmacological aspects.
- A tale of two cannabinoids.
- The endocannabinoid system as an emerging target of pharmacotherapy
- Care and feeding of the endocannabinoid system
- The therapeutic potential of cannabis and cannabinoids
- Non-psychotropic plant cannabinoids
- Therapeutic potential of cannabinoid-based drugs
- CBD as an anti-arrhythmic, the role of the CB1 receptors
- Is the cardiovascular system a therapeutic target for cannabidiol?
- CBD attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
- The Effect of CBD on Ischemia/Reperfusion-Induced Ventricular Arrhythmias
- Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
- CBD protects against myocardial ischemic reperfusion injury
- Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
- Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
- The endocannabinoid system: an emerging key player in inflammation
- Cannabinoids, endocannabinoids, and related analogs in inflammation
- Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
- Protective effect of CBD on hydrogen peroxide‑induced apoptosis, inflammation and oxidative stress in nucleus pulposus cells
- Endocannabinoid 2-arachidonoylglycerol protects inflammatory insults from sulfur dioxide inhalation via cannabinoid receptors in the brain
- Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
- Cannabinoids, inflammation, and fibrosis
- Cannabinoids in clinical practice
- Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
- Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
- Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
- Antioxidant function of phytocannabinoids: Molecular basis of their stability and cytoprotective properties under UV-irradiation
- Cannabis for inflammatory bowel disease.
- Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study.
- Cannabis use amongst patients with inflammatory bowel disease.
- Cannabidiol in inflammatory bowel diseases: a brief overview.
- Cannabinoids and GI Disorders: Endogenous and Exogenous
- CBD reduces intestinal inflammation through the control of neuroimmune axis
- CBD and gastrointestinal motility
- Endocannabinoids and the gastrointestinal tract
- CBD and the gut: New developments and emerging concepts
- Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)
- The endocannabinoid system and liver diseases
- Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death
- Potential of CBD for the Treatment of Viral Hepatitis
- Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
- Phytocannabinoids-A Green Approach toward Non-Alcoholic Fatty Liver Disease Treatment
- Cannabinoids and hallucinogens for headache
- The endocannabinoid system and migraine
- Variations in the cannabinoid receptor 1 gene predispose to a migraine
- Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
- The Use of Cannabis and Cannabinoids in Treating Symptoms of Multiple Sclerosis: a Systematic Review of Reviews.
- Cannabis use by individuals with multiple sclerosis: effects on specific immune parameters.
- Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids.
- CBD provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
- Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
- CBD counteracted the development of experimental MS
- Cannabidiol to Improve Mobility in People with Multiple Sclerosis.
- Immunomodulatory Potential of Cannabidiol in Multiple Sclerosis: a Systematic Review
- Molecular Targets of Cannabidiol in Neurological Disorders
- CBD: A promising drug for neurodegenerative disorders?
- CBD for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?
- Neurological aspects of the medical use of CBD
- CBD reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke
- CBD Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells
- CBD reduces neuroinflammation and promotes neuroplasticity and functional recovery after brain ischemia
- Cannabidiol, neuroprotection and neuropsychiatric disorders
- Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
- The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
- Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?
- The endocannabinoid system in obesity and type 2 diabetes
- Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk
- Cannabinoids and endocannabinoids in metabolic disorders with a focus on diabetes
- Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population.
- Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain.
- Medical Cannabis Use Is Associated With Decreased Opiate Medication Use in a Retrospective Cross-Sectional Survey of Patients With Chronic Pain.
- CBD Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
- Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies
- Cannabinoids and bone: Friend or Foe?
- Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells
- Skeletal lipidomics: Regulation of bone metabolism by fatty acid amide family
- Long-chain polyunsaturated fatty acids may mutually benefit both obesity and osteoporosis
- Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
- Peripheral cannabinoid receptor, CB2, regulates bone mass
- Natural products as alternative treatments for metabolic bone disorders and for maintenance of bone health
- Cannabinoid receptors and the regulation of bone mass
- Endocannabinoids and the regulation of bone metabolism
- The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption
- The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy
- Cannabinoids and the skeleton: From marijuana to reversal of bone loss
- Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases
- A selective review of medical cannabis in cancer pain management
- Topical Medical Cannabis: A New Treatment for Wound Pain-Three Cases of Pyoderma Gangrenosum.
- Cannabidiol: promise and pitfalls.
- Cannabis for Chronic Pain: Challenges and Considerations.
- Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids.
- Medical cannabis in the treatment of cancer pain and spastic conditions and options of drug delivery in clinical practice
- Re-branding cannabis: the next generation of chronic pain medicine?
- Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands.
- Marijuana extract helps prevent chemo pain
- Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain
- CB2 Receptors Activation Protects against Oxidative Stress and Neuroinflammation Associated Dopaminergic Neurodegeneration in Rotenone Model of Parkinson’s Disease
- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease
- Cannabidiol for the treatment of psychosis in Parkinson’s disease
- Cannabidiol can improve complex sleep-related behaviors associated with rapid eye movement sleep behavior disorder in Parkinson’s disease patients
- Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson’s disease
- Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: a prospective cohort study
- The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD
- Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
- CBD blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors
- Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence
- Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit
- Non-antidepressant long-term treatment in post-traumatic stress disorder
- CBD Modulates Fear Memory Formation Through Interactions with Serotonergic Transmission in the Mesolimbic System
- Bidirectional Effects of CBD on Contextual Fear Memory Extinction
- The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent
- Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex
- Cannabis, Cannabinoids, and Sleep: a Review of the Literature
- Endocannabinoid Signaling Regulates Sleep Stability
- Endocannabinoid modulation of cortical up-states and NREM sleep
- Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
- Endocannabinoids and stress
- Stress regulates endocannabinoid-CB1 receptor signaling
- Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
- Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output
- Neuromodulators, stress, and plasticity: a role for endocannabinoid signaling
- Endogenous cannabinoid signaling is essential for stress adaptation
- Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders
- Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus
- Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance
- Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory
- Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis
- Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
- Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
- Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism
- CBD reduces brain damage and improves functional recovery in a neonatal rat model of arterial ischemic stroke
- Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice
The Australian Therapeutics Goods Administration (TGA) has also compiled a few good resources on cannabis for medical professionals.